Thorlabs

Demo Thorlabs’ OCT Technologies at BiOS and PWEST 2023

You are invited to visit Thorlabs’ OCT team at SPIE BiOS (Booth #8331) January 28 – 29 and Photonics West (Booth #627) January 31 – February 2 in San Francisco at the Moscone Center. We will have three live OCT systems on site and would like to invite you to bring your samples for a live demo, speak with our experts, and collect the newest Thorlabs T-shirt. For those building their own OCT setups, we can walk you through a variety of integral components, such as SLDs, MEMS-VCSEL benchtop lasers, specialized fibers, and bulk optics, as well as our brand-new OCT spectrometer. Alternatively, if you have an application need but no system, come in and check out our turn-key OCT solutions based on either swept-source or spectral-domain technology. Our systems are ideal for applications in biomedicine, industrial quality control, and more. Learn more at https://youtu.be/erDiuKNoHFI. We look forward to seeing you soon!

Thorlabs Adds Holographic Grating Spectrometer to Its OCT Portfolio

Thorlabs announced today that it has expanded its Spectral-Domain OCT (SD-OCT) offering with the release of the HG10 Holographic Grating Spectrometer, a fiber-based, high-speed spectrometer that provides sub-nanometer resolution in the optical range of 810 to 965 nm.  With an acquisition speed of up to 130 kHz, USB 3.0 connection, external synchronization options via a TTL trigger input, and rigid design, the HG10 spectrometer is ideal for stable and rapid spectrum acquisition. It is based on the ones used in Thorlabs’ well-established turnkey Ganymede™ Series of Optical Coherence Tomography (OCT) imaging systems and has been designed to support easy integration into laboratory setups.  “The development of the HG10 was a logical step and the direct result of feedback we received from customers that they wanted to have the same low roll-off and high-sensitivity performance offered by our turnkey OCT systems available for their laboratory setups,” sai...

SC4500 supercontinuum source for mid-IR OCT imaging

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Optical coherence tomography (OCT) is a well-established technique for non-destructive and non-contact three-dimensional structural imaging of complex samples. OCT systems are versatile, providing high spatial performance and high sensitivity at high imaging speed. For these reasons, OCT methods operating in the visible and near-infrared (near-IR) spectral ranges are the gold standard for various biomedical research and diagnostics. Advances and developments in mid-IR light sources and detection technologies have re- cently enabled OCT to move further towards longer wavelengths. Several reports on mid-IR OCT imaging have been published over the past few years, starting in 2018. OCT in the mid-IR spectral range is still in the research and development phase but is already attracting a lot of attention due to its superior immunity to scattering. Thus, mid-IR OCT systems facilitate increased probing depth for high-scattering (e.g., porous, turbid) materials. This opens up various new a...

Non-destructive mapping of stress and strain in soft thin films through sound waves

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Measuring the in-plane mechanical stress in a taut membrane is challenging, especially if its material parameters are unknown or altered by the stress. Yet being able to measure the stress is of fundamental interest to basic research and practical applications that use soft membranes, from engineering to tissues. Here, we present a robust non-destructive technique to measure directly in-situ stress and strain in soft thin films without the need to calibrate material parameters. Our method relies on measuring the speed of elastic waves propagating in the film. Using optical coherence tomography, we verify our method experimentally for a stretched rubber membrane, a piece of cling film (about 10 μm thick), and the leather skin of a traditional Irish frame drum. We find that our stress predictions are highly accurate and anticipate that our technique could be useful in applications ranging from soft matter devices to biomaterial engineering and medical diagnosis. ( Read Full Article )

Electro-Optical Test Engineer ar Thorlabs, Inc

Founded in 1989, Thorlabs seeks to accelerate the forward movement of scientific discovery and advancement! As a vertically integrated manufacturer of photonics components, instruments, and systems, our vast product portfolio includes over 20,000 items, ranging from optics and optomechanical positioning components to imaging systems, many of which are customer inspired. Photonics is the foremost technology driving innovation in science and engineering. As the number of technological innovations has grown, Thorlabs has extended its core competencies in an effort to play an ever increasing role serving the Photonics Industry at the research end, as well as the industrial, life science, medical, and defense segments. Headquartered in Newton, NJ, Thorlabs has grown to over Approximately 2,300 employees with manufacturing and sales offices in the United States, United Kingdom, Germany, France, Sweden, Japan, China, and Brazil. As light-based technologies push into new markets, Thorlabs p...

Imaging Solutions Engineer at Thorlabs, Inc

Founded in 1989, Thorlabs seeks to accelerate the forward movement of scientific discovery and advancement! As a vertically integrated manufacturer of photonics components, instruments, and systems, our vast product portfolio includes over 20,000 items, ranging from optics and optomechanical positioning components to imaging systems, many of which are customer inspired. Photonics is the foremost technology driving innovation in science and engineering. As the number of technological innovations has grown, Thorlabs has extended its core competencies in an effort to play an ever increasing role serving the Photonics Industry at the research end, as well as the industrial, life science, medical, and defense segments. Headquartered in Newton, NJ, Thorlabs has grown to over Approximately 2,300 employees with manufacturing and sales offices in the United States, United Kingdom, Germany, France, Sweden, Japan, China, and Brazil. As light-based technologies push into new markets, Thorlabs p...

Reconstruction and Spectral Analysis for Optical Coherence Tomography – MathWorks

MATLAB code for reconstruction and spectral analysis of spectral domain OCT images. This code can be used as part of a platform for molecular imaging with OCT, which we call MOZART. This code was created to read raw interferograms from Thorlabs OCTs (SW version 4 works best, but version 3 is also supported with a few changes). It reconstructs the raw interferograms into OCT images, and supports both 2D, 3D and speckle variance. In addition to reconstructing the images this code: Calculates the normalized spcekle variance (useful for detecting blood vessels) Calculates dispersion compensation Calculates a map of spectral contras, based on dual-band spectral analysis Calculates spectral-depth compensation Creates images that combine the OCT image, spectral analysis and speckle variance. and more features... This code was used to create images and analysis for: "Contrast-enhanced optical coherence tomography with picomolar sensitivity for functional in vivo imaging" O Liba, ED SoRelle,...

Post Doc / research group leader for intravital imaging in airway at the Institute of Biomedical Optics, University of Lübeck

Post Doc / research group leader for intravital imaging in airway. The position is funded by long-running grant of the German Center of Lung Research, which fosters translational medical research in pulmonology. Salary will be in accordance with the collective German bargaining agreement for universities. Recent developments in OCT which aim to increase resolution and to improve contrast hold great promise for intravital imaging of human tissue at cellular resolution. Important applications are expected in imaging airways for the diagnosis of asthma, inflammatory, and neoplastic diseases. Within a small interdisciplinary team, the Post Doc shall develop and apply novel multimodal imaging technology such as OCT and fluorescence imaging for visualizing specific physiological and pathological processes of cystic fibrosis, asthma, and allergy down to a cellular level. The University of Lübeck is specialized in health sciences and holds vast expertise in medical imaging. I...

Multi-class classification of breast tissue using optical coherence tomography and attenuation imaging combined via deep learning

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We demonstrate a convolutional neural network (CNN) for multi-class breast tissue classification as adipose tissue, benign dense tissue, or malignant tissue, using multi-channel optical coherence tomography (OCT) and attenuation images, and a novel Matthews correlation coefficient (MCC)-based loss function that correlates more strongly with performance metrics than the commonly used cross-entropy loss. We hypothesized that using multi-channel images would increase tumor detection performance compared to using OCT alone. 5,804 images from 29 patients were used to fine-tune a pre-trained ResNet-18 network. Adding attenuation images to OCT images yields statistically significant improvements in several performance metrics, including benign dense tissue sensitivity (68.0% versus 59.6%), malignant tissue positive predictive value (PPV) (79.4% versus 75.5%), and total accuracy (85.4% versus 83.3%), indicating that the additional contrast from attenuation imaging is most beneficial for dis...

Dynamic microscopic optical coherence tomography to visualize the morphological and functional micro-anatomy of the airways

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In the imaging of airway tissue, optical coherence tomography (OCT) provides cross-sectional images of tissue structures, shows cilia movement and mucus secretion, but does not provide sufficient contrast to differentiate individual cells. By using fast sequences of microscopic resolution OCT (mOCT) images, OCT can use small signal fluctuations to overcome lack in contrast and speckle noise. In this way, OCT visualizes airway morphology on a cellular level and allows the tracking of the dynamic behavior of immune cells, as well as mucus transport and secretion. Here, we demonstrate that mOCT, by using temporal tissue fluctuation as contrast (dynamic mOCT), provides the possibility to study physiological and pathological tissue processes in vivo . ( Read Full Article )

Digital refocusing based on deep learning in optical coherence tomography

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We present a deep learning-based digital refocusing approach to extend depth of focus for optical coherence tomography (OCT) in this paper. We built pixel-level registered pairs of en face low-resolution (LR) and high-resolution (HR) OCT images based on experimental data and introduced the receptive field block into the generative adversarial networks to learn the complex mapping relationship between LR-HR image pairs. It was demonstrated by results of phantom and biological samples that the lateral resolutions of OCT images were improved in a large imaging depth clearly. We firmly believe deep learning methods have broad prospects in optimizing OCT imaging. ( Read Full Article )

Optical Coherence Tomography for Biofilm Research- Webinar April 13, 2022

Dr. Robert Nerenberg from the University of Notre Dame will join us to discuss how optical coherence tomography (OCT) has become an emerging tool for biofilm research, providing many new opportunities for biofilm imaging. Dr. Nerenberg will review his work and experience in the field as he explains how OCT can impact biofilm research in a positive way. Some examples he will review include time-lapse imaging of biofilm growth, real-time imaging of biofilm deformation and detachment, spatial mapping of biofilm cell density, effects of eukaryotic predation on biofilms, the development of filamentous structures in biofilms, and mapping biofilm development in porous plastic supports. This free, live event will take place on April 13th, 11 AM EST and will include an interactive Q&A session. For more information and to register please visit this link. After the event a recorded version will be available at www.thorlabs.com/webinars.   

Video-rate high-precision time-frequency multiplexed 3D coherent ranging

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Frequency-modulated continuous wave (FMCW) light detection and ranging (LiDAR) is an emerging 3D ranging technology that offers high sensitivity and ranging precision. Due to the limited bandwidth of digitizers and the speed limitations of beam steering using mechanical scanners, meter-scale FMCW LiDAR systems typically suffer from a low 3D frame rate, which greatly restricts their applications in real-time imaging of dynamic scenes. In this work, we report a high-speed FMCW based 3D imaging system, combining a grating for beam steering with a compressed time-frequency analysis approach for depth retrieval. We thoroughly investigate the localization accuracy and precision of our system both theoretically and experimentally. Finally, we demonstrate 3D imaging results of multiple static and moving objects, including a flexing human hand. The demonstrated technique achieves submillimeter localization accuracy over a tens-of-centimeter imaging range with an overall depth voxel acquisiti...

Retinal blood flow imaging with combined full-field swept-source optical coherence tomography and laser Doppler holography

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Full-field swept-source optical coherence tomography (FF-SS-OCT) and laser Doppler holography (LDH) are two holographic imaging techniques presenting unique capabilities for ophthalmology. We report on interlaced FF-SS-OCT and LDH imaging with a single instrument. Effectively, retinal blood flow and pulsation could be quasi-simultaneously monitored. This instrument holds potential for a wide scope of ophthalmic applications. ( Read Full Article )

Volumetric directional optical coherence tomography

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Photoreceptor loss and resultant thinning of the outer nuclear layer (ONL) is an important pathological feature of retinal degenerations and may serve as a useful imaging biomarker for age-related macular degeneration. However, the demarcation between the ONL and the adjacent Henle’s fiber layer (HFL) is difficult to visualize with standard optical coherence tomography (OCT). A dedicated OCT system that can precisely control and continuously and synchronously update the imaging beam entry points during scanning has not been realized yet. In this paper, we introduce a novel imaging technology, Volumetric Directional OCT (VD-OCT), which can dynamically adjust the incident beam on the pupil without manual adjustment during a volumetric OCT scan. We also implement a customized spoke-circular scanning pattern to observe the appearance of HFL with sufficient optical contrast in continuous cross-sectional scans through the entire volume. The application of VD-OCT for retinal imaging ...

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