Damae Medical

Technical Advancements in Line-Field Confocal Optical Coherence Tomography for Improving the Management of Skin Cancer

Line-field confocal optical coherence tomography (LC-OCT) is an imaging technique based on a combination of reflectance confocal microscopy and time-domain OCT. It can generate cellular-resolution vertical images, horizontal cross-sectional images, and three-dimensional (3D) images, yielding the possibility for optical biopsies of skin tissue in vivo and in real time.Jonas Ogien, Ph.D., of DAMAE Medical introduces the basic principles of LC-OCT and shares an overview of new technical advancements based on the technique. These advancements aim to create new workflows for improved skin cancer management. In particular, he presents how a secondary optical path added to the technique to obtain dermoscopic color images of the surface of skin in parallel to the LC-OCT images. This allows for both accurate positioning on a lesion and the ability to check the coverage of the lesion image. Ogien then demonstrates how a video mosaic algorithm makes it possible to follow surgical margins whi...

Mirau-based line-field confocal optical coherence tomography for three-dimensional high-resolution skin imaging

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Significance: Line-field confocal optical coherence tomography (LC-OCT) is a recently introduced high-resolution imaging modality based on a combination of low-coherence optical interferometry and reflectance confocal optical microscopy with line illumination and line detection. Capable of producing three-dimensional (3D) images of the skin with cellular resolution, in vivo , LC-OCT has been mainly applied in dermatology and dermo-cosmetology. The LC-OCT devices capable of acquiring 3D images reported so far are based on a Linnik interferometer using two identical microscope objectives. In this configuration, LC-OCT cannot be designed to be a very compact and light device, and the image acquisition speed is limited. Aim: The objective of this work was to develop a more compact and lighter LC-OCT device that is capable of acquiring images faster without significant degradation of the resolution and with optimized detection sensitivity. Approach: We developed an LC-OCT device based on...

Ex-vivo Examination of Excisions of Skin Tumors by Confocal Optical Coherence Tomography (LC-OCT) With Integrated Dermoscopy and Comparison With Histology (DERMOCTAV)

There are mainly 3 types of skin cancer: melanoma, basal cell carcinoma and squamous cell carcinoma. The diagnosis of skin cancers is now based on anatomo-pathological evidence. However, given the progress made, imaging is a technique that now has a full role in the diagnosis of these pathologies. This is particularly the case of confocal optical coherence tomography (LC-OCT), which is a recent imaging technique that has proven itself in ophthalmology with the obtaining of precise images of the retina. LC-OCT can be applied in dermatology according to the following principle: the low intensity laser beam delivered by the LC-OCT device interferes with the melanin, is reflected and makes it possible to instantly acquire a 3D cross-sectional image of the skin, with a resolution of the order of a micrometer. It is finally an "optical echography", the light allowing a tissue definition much higher than the ultrasonic waves. It is therefore possible to obtain sections of histological reso...

Damae Medical raises €5M in Series A Financing to accelerate the European deployment of its deepLive platform and revolutionize skin cancer screening, diagnosis and monitoring

  Major investments in the development of new product functionalities and artificial intelligence (AI) solutions to redefine the management of skin cancers Commercial acceleration in Europe, particularly in France, Germany and Italy of the deepLive™ platform First clinical validations in the United States and Australia Damae Medical, a medtech company developing optical imaging medical devices and AI software platform to help dermatologists manage their patients, announced today the closing of a €5 million Series A financing. Advised by Klever Invest, the round was led by BNP Paribas Développement and followed by the historical investors Kurma Partners and Paris Saclay Seed Fund. Anaïs Barut, co-founder and CEO of Damae Medical declared: “The primary ambition of Damae Medical and our deepLive™ medical device is to revolutionize the management of skin cancers. This is what we have achieved by collaborating with the best academic hospitals aro...

Damae Medical DeepLive™ – Digital Optical Biopsy for Dermatology

DAMAE Medical develops deepLive™ medical device, the new best-in-class imaging system pairing penetration and cellular resolution in 3D. deepLive™ integrates LC-OCT (Line-field Confocal Optical Coherence Tomography) technology which provides a unique 3D imaging modality, allowing the user to switch from a histology-like vertical mode to a confocal-like horizontal mode, and to record a 3D stack of tissue volumes in situ. deepLive™ is adapted to the imaging of multiple skin conditions, promoting efficient, reassuring and non-invasive patient management. For more information, please contact us by email: info@damae-medical.com ( Read Full Article )

Line-field confocal optical coherence tomography for three-dimensional skin imaging

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This paper reports on the latest advances in line-field confocal optical coherence tomography (LC-OCT), a recently invented imaging technology that now allows the generation of either horizontal ( x × y ) section images at an adjustable depth or vertical ( x × z ) section images at an adjustable lateral position, as well as three-dimensional images. For both two-dimensional imaging modes, images are acquired in real-time, with real-time control of the depth and lateral positions. Three-dimensional ( x × y × z ) images are acquired from a stack of horizontal section images. The device is in the form of a portable probe. The handle of the probe has a button and a scroll wheel allowing the user to control the imaging modes. Using a supercontinuum laser as a broadband light source and a high numerical microscope objective, an isotropic spatial resolution of ∼1 µm is achieved. The field of view of the three-dimensional images is 1.2 mm × 0.5 mm &ti...

Mirau-based line-field confocal optical coherence tomography

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Line-field confocal optical coherence tomography (LC-OCT) is an imaging technique in which A-scans are acquired in parallel through line illumination with a broadband laser and line detection with a line-scan camera. B-scan imaging at high spatial resolution is achieved by dynamic focusing in a Linnik interferometer. This paper presents an LC-OCT device based on a custom-designed Mirau interferometer that offers similar spatial resolution and detection sensitivity. The device has the advantage of being more compact and lighter. In vivo imaging of human skin with a resolution of 1.3 µm × 1.1 µm (lateral × axial) is demonstrated over a field of 0.9 mm × 0.4 mm (lateral × axial) at 12 frames per second. ( Read Full Article )

Dual-mode line-field confocal optical coherence tomography for ultrahigh-resolution vertical and horizontal section imaging of human skin in vivo

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Line-field confocal optical coherence tomography (LC-OCT) is a recently introduced technique for ultrahigh-resolution vertical section (B-scan) imaging of human skin in vivo . This work presents a new implementation of the LC-OCT technique to obtain horizontal section images (C-scans) in addition to B-scans. C-scan imaging is achieved with this dual-mode LC-OCT system using a mirror galvanometer for lateral scanning along with a piezoelectric chip for modulation of the interferometric signal. A quasi-identical spatial resolution of ∼ 1 µm is measured for both B-scans and C-scans. The images are acquired in both modes at a rate of 10 frames per second. The horizontal field of view of the C-scans is 1.2 × 0.5 mm 2 , identical to the vertical field of view of the B-scans. The user can switch between the two modes by clicking a button. In vivo cellular-resolution imaging of human skin is demonstrated in both B-scan and C-scan modes, with the possibility to navigate withi...

New Device Performs 3D “Optical Biopsies” Of Skin

DAMAE Medical and NKT Photonics have worked together under the Eurostar financing program to combine the cutting-edge Line-field Confocal Optical Coherence Tomography (LC-OCT) imaging technology, developed by DAMAE Medical, with the innovative supercontinuum laser technology provided by NKT Photonics.  With a broadband SuperK white light laser as a key component, DAMAE Medical has developed an in vivo skin imaging device which performs “optical biopsies” based on the new LC-OCT technology. This unique technique couples the technological advantages of OCT and confocal microscopy: high resolution at high penetration depth. The broadband near-infrared light from the laser combined with high aperture microscope objectives guarantee an isotropic cellular resolution of 1 micron. With the combination of 3 imaging modes – vertical, horizontal, and 3D – the handheld imaging probe enables the dermatologist to visualize the epidermis and dermis in real-time; and g...

Industrialization Engineer Position Opening a DAMAE Medical

DAMAE Medical has implemented a plan to industrialize its imaging system. A production process must be defined and deployed accordingly. This position is part of the need to move from a prototype / pre-series stage to an industrialization stage of the company's products, in close collaboration with the R&D, clinical and marketing teams. In this context, your missions will consist in: Supporting the R&D team in the industrial development phase of the products (feasibility, design, optimization): According to constraints of performance, ergonomics, safety, robustness, reliability, and costs. Contribute to the verification and validation phases (qualification, calibration, monitoring and maintenance strategies). Guarantee the product's manufacturability constraints according to industrial methods. Managing design transfer into production: Define and organize manufacturing methods according to productivity and quality requirements (DMR – Device Master Record, controls)....

Product R&D Engineer Position Opening at DAMAE Medical

You will join the company's R&D team and become a key element in the development and industrialization of our medical devices. Your missions will consist in: Participating in engineering studies: design and/or improvement of optical or mechanical functions, prototyping of electronic boards. Document / update the design file (nomenclature, drawing...) and send it to subcontractors for manufacturing. Assembly and integration into the device, experimental tests and validation. Taking charge of the verification and validation phases of product design: Definition of the qualification strategy (performance metrics, functional tests, calibration, robustness...). Creation of associated test plans, execution of tests and reports. Management and correction of bugs and NCs, tracking of traceability. Development oaf associated tools (test benches, software, automation). Valuation of qualification results to define monitoring and maintenance strategies for the devices. Contributing to inst...

Line-field confocal time-domain optical coherence tomography with dynamic focusing

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A time-domain optical coherence tomography technique is introduced for high-resolution B-scan imaging in real-time. The technique is based on a two-beam interference microscope with line illumination and line detection using a broadband spatially coherent light source and a line-scan camera. Multiple (2048) A-scans are acquired in parallel by scanning the sample depth while adjusting the focus. Quasi-isotropic spatial resolution of 1.3 µm × 1.1 µm (lateral × axial) is achieved. In vivo cellular-level resolution imaging of human skin is demonstrated at 10 frames per second with a penetration depth of ∼500 µm. ( Read Full Article )

Line-field confocal optical coherence tomography for high-resolution noninvasive imaging of skin tumors

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An optical technique called line-field confocal optical coherence tomography (LC-OCT) is introduced for high-resolution, noninvasive imaging of human skin in vivo . LC-OCT combines the principles of time-domain optical coherence tomography and confocal microscopy with line illumination and detection using a broadband laser and a line-scan camera. LC-OCT measures the echo-time delay and amplitude of light backscattered from cutaneous microstructures through low-coherence interferometry associated with confocal spatial filtering. Multiple A-scans are acquired simultaneously while dynamically adjusting the focus. The resulting cross-sectional B-scan image is produced in real time at 10  frame  /  s. With an isotropic spatial resolution of ∼1  μm, the LC-OCT images reveal a comprehensive structural mapping of skin at the cellular level down to a depth of ∼500  μm. LC-OCT has been applied to the imaging o...

Three Innovation Start-ups on the Move

Damae Medical working to diagnose skin tumors without a biopsy The start-up’s rapid and non-invasive technology is now in the pre-industrialization phase. Diagnosing skin cancer requires a biopsy, which is to say analyzing a patient’s tissue sample with a microscope. Damae Medical, which grew out of research conducted at the Laboratoire Charles-Fabry, 2 is aiming to revolutionize this exam. The technology developed by Damae Medical will provide dermatologists with an in vivo imaging modality that produces in-depth images of the tissue similar to histology without the need for skin tissue excision and processing. Co-founder and Chief Scientific Officer Pr. Arnaud Dubois focused on a single question: how to image biological tissue mass on the cellular scale of a few microns. Such tissue actually acts as a diffusive environment on light, similar to frosted glass, as rays do not propagate in straight lines and quickly lose all “memory” of their origin, thereby bl...

The Future of Boston’s Medical Device Community May Include a Decidedly French Accent

For two early stage French medical device companies, the upcoming MassMedic MedTech Showcase could be a game changer.  The more than 300 event attendees, including investors and potential business partners, could be a determining factor on whether either company gets an opportunity to become part of the region’s coveted healthcare community. The two French start-ups – DAMAE Medical and Neurallys – are being awarded by the City of Boston and the Greater Boston Chamber of Commerce the “Paris Boston MedTech Award” as recognition of their innovation and their potential for entry into the US market. They were selected by a bi-national jury composed of French Tech Hub – the largest French startups accelerator in the US with an office in Boston – and MassMedic (Massachusetts medical devices industrial alliance). Last year’s winner of the award, Biomodex, has since relocated its CEO to Boston a...


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