Patents

Systems and methods for automated widefield optical coherence tomography angiography

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Disclosed are systems and methods for generating wide-field optical coherence tomography angiography (OCTA) images. In embodiments, multiple OCTA scans of a sample are automatically acquired at overlapping locations. The systems and methods include functionality to adaptively control the scanning procedure such that eye blink and eye motion events are detected in real time and accounted for during 3D scan acquisition. Also disclosed are methods for detecting and correcting motion-related artifacts in OCTA datasets which allow for the longer scan times over larger fields of view required for wide-field imaging. These methods may include division of en face angiogram images into a set of motion-free parallel strips, and application of gross and fine registration methods to align overlapping strips into a motion-corrected composite image. A series of overlapping motion-corrected composite images may be combined into a larger montage to enable wide-field OCTA imaging using multiple OCTA...

Compact briefcase OCT system for point-of-care imaging

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A detector for characterizing at least one of a middle ear fluid and a middle ear biofilm includes a handheld probe outputting near-infrared and visible light, an OCT system to obtain A-scans at a plurality of positions on a tympanic membrane, and a camera to obtain surface sub-images at the plurality of positions. A-scans and surface sub-images are synchronized and the surface sub-images are mosaicked to generate a surface image of the tympanic membrane. Cross-sectional scan images or a thickness map are generated from the synchronized A-scans and segmented to extract a plurality of specified features. The specified features are then classified to characterize at least one of the middle ear fluid and the middle ear biofilm. The detector, including handheld probe with camera, OCT system, and a laptop computer, is sized to fit into a handheld, portable, compact, foam-padded briefcase weighing less than 10 kg. ( Read Full Article )

Mapping ciliary activity using phase resolved spectrally encoded interferometric microscopy

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Ciliary motion in the upper airway is the primary mechanism by which the body transports foreign particulate out of the respiratory system. The ciliary beating frequency (CBF) is often disrupted with the onset of disease. Current imaging of ciliary motion relies on microscopy and high speed cameras, which cannot be easily adapted to in-vivo imaging. M-mode optical coherence tomography (OCT) imaging is capable of visualization of ciliary activity, but the field of view is limited. ( Read Full Article )

Neural network system for non-destructive optical coherence tomography

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A system and method for non-destructive optical coherence tomography (OCT) is provided. The system includes: an input interface for receiving OCT data including at least a C-scan; a processing unit executable to detect a feature on a surface or subsurface of the object, trained using a training set and configured to: separate the C-scan into A-scans; using a neural network, successively analyze each A-scan to detect the presence of an A-scan feature associated with the object; separate the C-scan into B-scans; segment each of the B-scans to determine thresholds associated with the object; using a neural network, successively analyze each ... ( Read Full Article )

Method of volumetric imaging of a sample

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The present disclosure provides a method of volumetric imaging of a sample. The method comprises providing a plurality of depth images of a region of interest of the sample using a volumetric imaging system. The region of interest is below a surface area of interest of the sample. Each depth image is associated with a layer or slice of the region of interest and the plurality of depth images together forming a volumetric image of the region of interest. The method further comprises providing a surface image of the surface area of interest of the sample and identifying a surface image property of a surface feature of the surface area of interest. The method also comprises processing the plurality of depth images of the region of interest using the surface image property of the surface feature to improve a property of the depth images of the region of interest. ( Read Full Article )

Visual field simulation using optical coherence tomography and optical coherence tomographic angiography

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Disclosed herein are methods for simulating the results of a visual field (VF) test using an optical coherence tomography (OCT) system. The disclosed methods may utilize structural information extracted from OCT image datasets, such as thickness measurements, or may utilize functional information, such as blood perfusion measurements, extracted from OCT angiography (OCTA) image datasets. Other embodiments may be described and claimed. ( Read Full Article )

Optical coherence tomography eye imaging techniques

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Aspects of the present disclosure provide improved techniques for imaging a subject's retina fundus. Some aspects relate to an imaging apparatus that may be substantially binocular shaped and/or may house multiple imaging devices configured to provide multiple corresponding modes of imaging the subject's retina fundus. ( Read Full Article )

Longitudinal display of coronary artery calcium burden

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The present disclosure provides systems and methods to receiving OCT or IVUS image data frames to output one or more representations of a blood vessel segment. The image data frames may be stretched and/or aligned using various windows or bins or alignment features. Arterial features, such as the calcium burden, may be detected in each of the image data frames. The arterial features may be scored. The score may be a stent under-expansion risk. ( Read Full Article )

Bonded tunable VCSEL with bi-directional actuation

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A MEMS tunable VCSEL includes a membrane device having a mirror and a distal-side electrostatic cavity for displacing the mirror to increase a size of an optical cavity. A VCSEL device includes an active region for amplifying light. Then, a proximal-side electrostatic cavity is defined between the VCSEL device and the membrane device is used to displace the mirror to decrease a size of an optical cavity. ( Read Full Article )

Optical coherence tomography for cancer screening and triage

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A device for cancer screening and triage using an optical coherence tomography (OCT) imaging system integrated with optical imaging probe is provided. Endoscopic OCT images are generated using the OCT system having a helical probe. The images are further analyzed to generate a depth resolved intensity OCT signal to classify the region of tissue into variable grades of dysplasia to guide the physician's biopsy or resection. ( Read Full Article )

Scalable optical coherence tomography imaging device

An optical coherence tomography imaging device (OCT device) splits laser light emitted from a light source into measurement light for irradiating an object and reference light for irradiating a reference mirror, then analyze the interference light formed by combining scattered measurement light reflected back from the object and reflected reference light reflected from the reference mirror in order to generate tomographic images. An OCT device includes a probe, which is used for irradiating the object with measurement light and collecting scattered measurement light that is reflected back from the object, and an OCT main unit, which includes a light source for emitting measurement light. The probe is arranged on an odonto-therapy unit equipped with an instrument hanger, and includes a probe-connection optical fiber for transmitting measurement light and scattered measurement light. The probe-connection optical fiber is detachably connected to the OCT main unit. ( Read Full Artic...

Ophthalmic imaging apparatus and storage medium

An ophthalmic imaging apparatus includes an OCT optical system that detects an interference signal between measurement light with which a subject eye is irradiated and reference light, and acquires OCT data of the subject eye by processing the interference signal, a scanner that scans with the measurement light on a scanning line on the subject eye, and a processor. ( Read Full Article )

Processing apparatus, fingerprint image extraction processing apparatus, system, processing method, and computer readable medium

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A technique for accurately extracting a fingerprint image for accurate authentication from 3D tomographic luminance data of a finger at a high speed. A processing apparatus (11) according to the present disclosure includes means for, after performing edge detection processing on a tomographic image (101, 102, . . . 10 k, . . . , 10n) at each depth, calculating the total number of edge pixels in the tomographic image from 3D (three-dimensional) tomographic luminance data, and acquiring depth dependence of the number of edges (111, 112), and means for extracting a tomographic image having a striped pattern from the depth dependence of the number of edges and the 3D tomographic luminance data. ( Read Full Article )

Atherectomy catheters with imaging

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An atherectomy catheter includes an elongate flexible catheter body, an elongate deflectable distal tip coupled to the catheter body at a hinge point, a rotatable cutter near the distal end of the catheter body, and a drive shaft extending within the catheter body and configured to rotate the cutter. The atherectomy catheter further includes an optical fiber extending through the drive shaft substantially on-axis with the catheter body and attached to the cutter. The optical fiber is configured to rotate with the drive shaft. The atherectomy catheter further includes a wedge configured to deflect the distal tip away from the catheter body at the hinge point upon axial movement of the drive shaft.   ( Read Full Article )

OCT measuring device and OCT measuring method

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OCT measuring device in the present exemplary embodiment includes: wavelength sweep light source that emits light of which a wavelength is swept; optical interferometer that divides the light into measurement light and reference light, emits measurement light toward measurement surface of measuring target object, and generates an optical interference intensity signal indicating an intensity of interference between measurement light reflected from measurement surface and reference light; electro-optic element which is a phase modulator arranged in a light path of optical interferometer; measurement processor which is a signal generator that derives a position of measurement surface and generates a phase amount ... ( Read Full Article )

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