Funding

Leadoptik Funding

Leadoptik is developing integrated optic technology for the pulmonology market and has raised a total of $1.8M in funding over 5 rounds. Their latest funding was raised on Jun 7, 2022 from a Non-equity Assistance round.

University of Alabama at Birmingham Receives NIH Grant for Functional Categorization of Ciliary Motion in PCDt

University of Alabama at Birmingham Receives a 2023 NIH Grant for $159,882 for Functional Categorization of Ciliary Motion in PCDt.  The principal investigator is George Solomon.  Below is a summary of the proposed study. Primary Ciliary Dyskinesia (PCD) is a genetically heterogeneous disorder of motile cilia that results in progressive lung disease due to abrogated mucociliary clearance. While new understandings of the genetics have been helpful for clinical diagnostics, functional testing of cilia are needed to understand and predict phenotypic variation and response to therapy. Recent work in our laboratory has identified a link between ciliary genetics and novel ciliary phenotypes using one-micron optical coherence tomography (µOCT). We have phenotyped the ciliary beating pattern of known and novel murine PCD models. We have extended this work to humans through the use of human nasal epithelial cells. Using these technologies, we will characterize and quantify functional cili...

University of Southern California Receives NIH Grant for Mechanisms of cochlear synaptopathy after noise or blast trauma

University of Southern California Receives a 2023 NIH Grant for $516,926 for Mechanisms of cochlear synaptopathy after noise or blast trauma.  The principal investigator is John S. Oghalai.  Below is a summary of the proposed study. About 15% of Americans have hearing loss due to noise exposure. The classical explanation is trauma to the cochlear hair cells. An additional mechanism of noise-induced hearing loss is cochlear synaptopathy. There are no effective treatments used clinically to prevent hearing loss via either mechanism after traumatic noise exposure. Recently, we identified that endolymphatic hydrops occurs after blast or noise trauma, and that endolymphatic hydrops correlated with cochlear synaptopathy. Our central hypothesis is that endolymphatic hydrops is a surrogate marker for swelling of auditory nerve dendrites that occurs in response to glutamate excitotoxicity. We will test this hypothesis with three aims. First, we will determine whether swelling of auditory ...

University of Oklahoma Receives NIH Grant for Use of 3D Quantitative Optical Methods to Optimize Mebendazole Treatment of Ovarian Cancer

University of Oklahoma received a 2023 NIH Grant for $162,748 for Use of 3D Quantitative Optical Methods to Optimize Mebendazole Treatment of Ovarian Cancer.  The principal investigator is Lauren Elizabeth Dockery.  Below is a summary of the proposed study. Effective treatment for recurrent epithelial ovarian cancer is a major, unmet public health need as the response rates of the patients are often low with the traditional chemotherapy. Repurposing drugs is an increasingly popular strategy in oncology due to the financial and logistical constraints of new drug development. Recently, anti-parasitic drugs such as mebendazole have surfaced as repurposed oncology drugs and showed promise in treating multiple types of tumors. The anti-parasitic drugs, fenbendazole and mebendazole, are in the benzimidazole class and have been FDA-approved to treat pinworm and other helminthic infections in humans and animals for decades. The selectivity of these drugs for the parasite rather than the ...

Washington University Receives NIH Grant for High-throughput integrated live imaging and optogenetic pacing platform to assess hypoxia responsiveness in the fly heart

Washington University received a 2023 NIH Grant for $432,968 for High-throughput integrated live imaging and optogenetic pacing platform to assess hypoxia responsiveness in the fly heart.  The principal investigator is Chao Zhou.  Below is a summary of the proposed study. Ischemic preconditioning is a well-established phenomenon, in which a brief episode(s) of controlled ischemia and reperfusion renders cardioprotection from a subsequent sustained episode of ischemia. An emerging body of evidence demonstrated that neural regulated heart rate modulation confers cardiac preconditioning responses. Understanding the mechanism through model systems of preconditioning would help us identify the genes and proteins when designing future drug targets for the prevention of ischemic cardiac injury. As a promising alternative to electrical pacing to modulate heart rate, optogenetic pacing does not require physical contact, has high spatial and temporal precision, offers more specific excitat...

Medical College of Wisconsin Receives NIH Grant for Otitis Media Diagnosis and Treatment

Medical College of Wisconsin Receives a 2023 NIH Grant for $497,472 for Otitis Media Diagnosis and Treatment.  The principal investigator is Joseph Kerchner.  Below is a summary of the proposed study Otitis media (OM) is the most common diagnosis in pediatric patients seen for illness in the United States (1,2), affects 90% of all children (3,4) and is the most common indication for antimicrobial therapy and surgery (5) in young children. Despite many attempts to improve diagnosis, treatment, and prevention, OM continues its highly prevalent impact on children and substantial ongoing morbidity (1,3,6-30). OM continues as the most common cause of hearing loss (HL) in children and leads to speech, educational and other developmental delays (31-37). OM causes life-threatening complications (22,27) and is expensive, resulting in over $5 billion annually in U.S. health care expenditures (3,38). Despite the prevalence and difficulties with OM, diagnostic accuracy to allow appropriate t...

Predicting acute and post-recovery outcomes in cerebral malaria and other comas by Optical Coherence Tomography (OCT)

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Children in Africa continue to die in large numbers from CM, mostly with severe brain swelling. New treatments for severe brain swelling and to reduce intracranial pressure (ICP) in CM are under clinical trial, but rely on MRI scans to identify severe brain swelling. Hardly any children with CM have access to MRI scanning, so those likely to benefit from new treatments are not identifiable. Children in coma for other causes would also benefit from the identification of raised intracranial pressure. Children who survive CM are at high risk of neurological and developmental complications. It is thought that this may be due to cerebral ischaemia but at present there is no method to identify these children other than waiting for their deficit to become manifest. Identifying CM patients at risk of neurological deficit or developmental delay would enable early intervention. Identifying a link between cerebral ischaemia and neurodevelopmental deficit (NDD) would also support the developm...

University of Applied Sciences, Jena Receives a BMBF Grant to Establish a Interdomain Framwork for an AI-based OCT-Data Image Analysis

The University of Applied Sciences, Jena has received a Federal Ministry of Education and Research (BMBF) grant for €799,558 to establish an Open Lab Framework for an AI-based interdomain OCT-Data analysis. The principal investigators are Prof. Dr. Dirk Schmalzried, Prof. Dr. Jens Bliedtner and Prof. Dr. Iwan Schie.   Within the project 'OpenLab AI - OpenLab for Data Analysis and Applied AI' a cross-domain framework for the analysis and processing of optical tomographic image data will be developed, which can be used cross-domain for the investigation of material surfaces in the domain of manufacturing and quality assurance as well as in the domain of medicine, e.g. for investigations of skin and retina data. This framework is intended to be a basis for an interdisciplinary teaching in data competencies in almost all faculties of the University of Applied Science Jena. Through cooperation and networking with local industry (Carl-Zeiss Meditec), research institutes (Leibniz...

DFG grants funding to quantify ocular blood flow

The German research foundation provides support to the Pattern Recognition Lab’s ophthalmic imaging group, led by Stefan Ploner, in the amount of more than a quarter million Euro, over a 30-month funding period. With this meanwhile third grant, DFG continues to strengthen a long standing collaboration in OCT(A) motion correction and signal reconstruction between the pattern recognition lab at FAU, led by Prof. Andreas Maier; the Biomedical Optical Imaging and Biophotonics group at MIT, led by the inventor of OCT, Prof. James Fujimoto; and clinicians at the New England Eye Center, led by retinal specialist Prof. Nadia Waheed. In this new project, we will merge two of our major research directions, bringing together retinal blood flow quantification ( Ploner et al., Retina, 2016 ) and OCT motion correction ( Kraus et al., BOEx, 2014 ; Ploner et al., MICCAI, 2022 ). Compared to classic static 3D OCTA vasculature analysis, we will develop methods for eye motion-corrected 4D (time-...

Massachusetts General Hosptial Receives NIH Grant for Screening for Barrett’s Esophagus Progressors with Multimodality Tethered Capsule Image-Guided Biopsy

Massachusetts General Hosptial Received a 2022 NIH Grant for $643,503 for Screening for Barrett's Esophagus Progressors with Multimodality Tethered Capsule Image-Guided Biopsy. The principal investigator is Guillermo Tearney. Below is a summary of the proposed study. Esophageal adenocarcinoma (EAC) is a deadly cancer that is preceded by a metaplastic change called Barrett's esophagus (BE). It has long been thought that endoscopic screening for BE followed by endoscopic surveillance can significantly decrease the mortality of EAC. This unfortunately has not borne out as the cost and inconvenience of conscious sedation prohibits endoscopy from being used as a population-based screening tool. BE screening may become possible in the future, owing to innovative swallowable tethered capsule endomicroscopes or cell sampling devices that can detect BE without requiring sedation. Yet, even if these capsules were to identify the large number of people in the US who have BE (~15M), endoscopic ...

Duke University Receives NIH Grant for Robotic Point-of-Care OCT

Duke University Received a 2022 NIH Grant for $97,825 for Robotic Point-of-Care OCT. The principal investigator is Mark Draelos. Below is a summary of the proposed study. The PI was previously funded by the F30 mechanism while completing the Duke Medical Scientist Training Program. He has since completed medical school and internship and now returns for a full-time research career. This career development proposal is an effective continuation of the PI’s prior mentored training and research experience and seeks to develop him into an independent investigator. The proposed project concerns the role of optical coherence tomography (OCT) in retinal disease screening. Preventable retinal blindness affects tens of millions of Americans and hundreds of millions worldwide. Its top three causes are chronic, progressive conditions that yield irreversible vision loss after an initial asymptomatic period. Annual screening is therefore essential to detect and treat these diseases before s...

University or Rochester Receives NIH Grant for Investigation of Brain Elasticity in Aging and Alzheimer’s Disease Enabled by Optical Coherence Elastography

University or Rochester Received a 2022 NIH Grant for $51,752 for Investigation of Brain Elasticity in Aging and Alzheimer's Disease Enabled by Optical Coherence Elastography. The principal investigator is Gary Ge. Below is a summary of the proposed study. The rapidly advancing field of “elastography” has had some major successes in answering basic science questions and improving clinical diagnostics and therapies. For example, increased liver stiffness is strongly correlated with advanced liver disease such as fibrosis, increased aortic stiffness has been linked with cardiovascular disease, and multiple cancers can be assessed with viscoelastic heterogeneity. Other studies have used the physical properties of tissue to investigate the relationship between structure and function, such as muscle contraction and corneal refraction of light. However, changes in the local and global biomechanical properties of brain tissue associated with aging and neurodegenerative diseases...

Duke University Receives NIH Grant for $504,051 for Secondary Data Analysis for Neonates with Retinal OCT Imaging

Duke University Received a 2022 NIH Grant for $257,350 for Secondary Data Analysis for Neonates with Retinal OCT Imaging. The principal investigator is Cynthia Toth. Below is a summary of the proposed study. The Secondary Data Analysis for Neonates with Retinal OCT Imaging includes data from 330 infant participants previously enrolled into prospective observational studies which included use of investigational OCT devices for imaging at the bedside. These data have been divided into two groups: the Retinopathy of Prematurity (ROP) Group and the Healthy Term Infant Group. The ROP Group consists of data from 239 preterm infants evaluated for ROP from the following studies: The Hartwell Foundation funded Spectral Domain Optical Coherence Tomography Imaging of Infant Eyes: A Practical Diagnostic Tool and Methodology, the Research to Prevent Blindness funded Association of Inflammatory Markers and Cystoid Macular Edema in Very Preterm Infants, a pilot National Center for Research Resourc...

University of Illinois at Chicago Receives NIH Grant for Differential artery-vein analysis in OCT angiography for objective classification of diabetic retinopathy

University of Illinois at Chicago Received a 2022 NIH Grant for $250,000 for Differential artery-vein analysis in OCT angiography for objective classification of diabetic retinopathy. The principal investigator is Xincheng Yao. Below is a summary of the proposed study. This is an administrative supplement application for the R01 project, entitled ‘Differential artery-vein analysis in OCT angiography for objective classification of diabetic retinopathy’ (R01EY030842). The purpose of this supplement application is to add artificial intelligence (AI) topic research for enhanced retinal image construction and automated artery-vein analysis. Potential impact of the proposed AI topic research is twofold: 1) to advance AI technology in eye health; 2) to training graduate students interested in AI technology. One underrepresented American-born-Vietnamese student and two African/black students from underdeveloped countries will be involved in this project. It is known that diabet...

New imaging technique could speed up development of eye disease treatments

Researchers have developed a simple and fast way to perform optoretinography, an imaging technique that measures light-induced functional activity in the eye's retina, the network of neurons in the back of our eyes responsible for detecting light and initiating vision. More than 50% of people in the U.S. over age 60 are affected by retinal diseases such as macular degeneration and diabetic retinopathy. ( Read Full Article )

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