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A normative database of wide-field swept-source optical coherence tomography angiography quantitative metrics in a large cohort of healthy adults

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Purpose Data from healthy eyes is needed to interpret optical coherence tomography angiography (OCTA) findings. However, very little normative data is available for wide-field swept-source OCTA (WF SS-OCTA), particularly 12 × 12-mm and disc-centered angiograms. Therefore, we aim to report quantitative metrics in a large sample of control eyes. Methods In this cross-sectional observational study, 482 eyes of 375 healthy adults were imaged on the 100 kHz Zeiss PLEX® Elite 9000 using protocols centered on the fovea (3 × 3, 6 × 6, and 12 × 12-mm) and optic disc (6 × 6 and 12 × 12-mm) between December 2018 and January 2022. The ARI Network (Zeiss Portal v5.4) was used to calculate vessel density (VD) and vessel skeletonized density (VSD) in the superficial capillary plexus, deep capillary plexus, and whole retina, as well as foveal avascular zone (FAZ) parameters. Mixed-effect multiple linear regression models were used for statistical analysis. Results The subjects’ m...

OCT and OCT Angiography Update: Clinical Application to Age-Related Macular Degeneration, Central Serous Chorioretinopathy, Macular Telangiectasia, and Diabetic Retinopathy

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Similar to ultrasound adapting soundwaves to depict the inner structures and tissues, optical coherence tomography (OCT) utilizes low coherence light waves to assess characteristics in the eye. Compared to the previous gold standard diagnostic imaging fluorescein angiography, OCT is a noninvasive imaging modality that generates images of ocular tissues at a rapid speed. Two commonly used iterations of OCT include spectral-domain (SD) and swept-source (SS). Each comes with different wavelengths and tissue penetration capacities. OCT angiography (OCTA) is a functional extension of the OCT. It generates a large number of pixels to capture the tissue and underlying blood flow. This allows OCTA to measure ischemia and demarcation of the vasculature in a wide range of conditions. This review focused on the study of four commonly encountered diseases involving the retina including age-related macular degeneration (AMD), diabetic retinopathy (DR), central serous chorioretinopathy (CSC), and...

SPIE Photonics West 2023 Preview

SPIE Photonics West 2023 Preview The SPIE Photonics West 2023 technical conference and exhibition is once again returning to The Moscone Center in San Francisco from January 28 to February 2, giving attendees the opportunity to learn about the latest innovations in lasers, photonics, optics, optoelectronics, biophotonics, biomedical optics, 3D printing and more. As in past years, the event will kick off with BiOS, the world’s largest biomedical optics conference, before transitioning into the Photonics West conference and exhibition. This year’s event is expected to host more than 20,000 attendees who will be able to browse the products and services of approximately 1,000 exhibitors, choose from over 50 educational courses, and access more than 4,400 technical papers during the conference. This year’s technical program consists of four separate conferences – BiOS, LASE, OPTO, and Quantum West – all designed to help attendees save time and energy by focusing on their areas of interest BiOS: Billed as “The most ...

PhD on Optical Coherence Tomography of the Eye in Low Resource Settings, University of Kent

      About the Project Criteria Open to Home students only. To be classed as a Home student, candidates must meet the RCUK residency criteria, see appendix B. The applicant must have a good background in theoretical and experimental optics and expected to have graduated Physics (Optics) or Electrical and Electronic Engineering. We are looking for a highly imaginative and self-motivated individual with expertise in optics, digital signal processing and programming languages such as LabVIEW, MatLab or C++. Further details We are recruiting for a fully funded PhD Studentships in Optics/Photonics/Physics for a period of 36 months with a start date in September 2023 within the Applied Optics Group, Division of Natural Sciences, University of Kent. The position is supported by the Global Challenges Doctoral Centre in the University of Kent. Optical Coherence Tomography (OCT), due to its non invasive and high resolution capabilities of imaging the human retina through...

Biofilm formation and inflammatory potential of Staphylococcus saccharolyticus: A possible cause of orthopedic implant-associated infections

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Staphylococcus saccharolyticus, a coagulase-negative staphylococcal species, has some unusual characteristics for human-associated staphylococci, such as slow growth and its preference for anoxic culture conditions. This species is a relatively abundant member of the human skin microbiota, but its microbiological properties, as well as the pathogenic potential, have scarcely been investigated so far, despite being occasionally isolated from different types of infections including orthopedic implant-associated infections. Here, we investigated the growth and biofilm properties of clinical isolates of S. saccharolyticus and determined host cell responses. Growth assessments in anoxic and oxic conditions revealed strain-dependent outcomes, as some strains can also grow aerobically. All tested strains of S. saccharolyticus were able to form biofilm in a microtiter plate assay. Strain-dependent differences were determined by optical coherence tomography, revealing that medium supplementa...

PhD studentship Opening in Optical Coherence Elastography ad University College London

    Primary Supervisor: Professor Peter Munro Secondary Supervisor: Dr Sami Sahmed, Professor Simon Arridge Project Summary A four-year fully funded PhD studentship, co-funded by the Royal Society, is available in UCL’s Computational Optics Group within the Department of Medical Physics. The successful candidate will be part of the UCL CDT in Intelligent, Integrated Imaging in Healthcare (i4health) and will benefit from the activities and events organised by the centre. The project will involve close interaction with researchers from UCL Hospital. The successful applicant can start at the beginning of the 2023/2024 academic year, or earlier. Background Oesophageal cancer is one of four cancers of “unmet need” (Cancer Research UK) mainly due to its poor survival rates and late diagnosis. Significant deficiencies exist at all stages of surveillance, staging, and treatment. We aim to overcome this problem using optical Coherence Elastogra...

Postdoctoral Research Fellowships (In Vivo Microscopy) at Massachusetts General Hospital

Employer Description Guillermo (Gary) J. Tearney, M.D., Ph.D. Tearney Lab – Wellman Center for Photomedicine Massachusetts General Hospital The Tearney Lab is an 80+ person multidisciplinary lab led by Guillermo (Gary) Tearney, MD, PhD. The goal of the Tearney Lab is to see every cell in the human body so that disease can be detected at its earliest stages when it can be cured.  To this end, the lab has pioneered multiple optical coherence tomography (OCT) devices that enable 3D imaging at the microscopic scale in living human patients. These technologies include multimodality OCT where OCT is combined with spectroscopy, fluorescence, and other optical techniques, ultrahigh-resolution OCT (µOCT) where the resolution is sufficiently detailed to visualize individual cells, and functional OCT that measures the function and metabolism of cells in living systems. These technologies are implemented in a variety of devices (endoscopes, catheters, capsules, implan...

Postdoctoral Research Fellowships (OCT Image Processing and Machine Learning) at Massachusetts General Hospital

Employer Description Guillermo (Gary) J. Tearney, M.D., Ph.D. Tearney Lab – Wellman Center for Photomedicine Massachusetts General Hospital  The Tearney Lab is an 80+ person multidisciplinary lab led by Guillermo (Gary) Tearney, MD, PhD. The goal of the Tearney Lab is to see every cell in the human body so that disease can be detected at its earliest stages when it can be cured.  To this end, the lab has pioneered multiple optical coherence tomography (OCT) devices that enable 3D imaging at the microscopic scale in living human patients. These technologies include multimodality OCT where OCT is combined with spectroscopy, fluorescence, and other optical techniques, ultrahigh-resolution OCT (µOCT) where the resolution is sufficiently detailed to visualize individual cells, and functional OCT that measures the function and metabolism of cells in living systems. These technologies are implemented in a variety of devices (endoscopes, catheters, capsules, ...

Postdoctoral Research Fellowships (Optical Coherence Tomography) at Massachusetts General Hospital

Employer Description Guillermo (Gary) J. Tearney, M.D., Ph.D. Tearney Lab – Wellman Center for Photomedicine Massachusetts General Hospital  The Tearney Lab is an 80+ person multidisciplinary lab led by Guillermo (Gary) Tearney, MD, PhD. The goal of the Tearney Lab is to see every cell in the human body so that disease can be detected at its earliest stages when it can be cured.  To this end, the lab has pioneered multiple optical coherence tomography (OCT) devices that enable 3D imaging at the microscopic scale in living human patients. These technologies include multimodality OCT where OCT is combined with spectroscopy, fluorescence, and other optical techniques, ultrahigh-resolution OCT (µOCT) where the resolution is sufficiently detailed to visualize individual cells, and functional OCT that measures the function and metabolism of cells in living systems. These technologies are implemented in a variety of devices (endoscopes, catheters, capsules, ...

Data Scientist Opening in Optical Coherence Tomography at Massachusetts General Hospital

Employer Description Guillermo (Gary) J. Tearney, M.D., Ph.D. Tearney Lab – Wellman Center for Photomedicine Massachusetts General Hospital  The Tearney Lab is an 80+ person multidisciplinary lab led by Guillermo (Gary) Tearney, MD, PhD. The goal of the Tearney Lab is to see every cell in the human body so that disease can be detected at its earliest stages when it can be cured.  To this end, the lab has pioneered multiple optical coherence tomography (OCT) devices that enable 3D imaging at the microscopic scale in living human patients. These technologies include multimodality OCT where OCT is combined with spectroscopy, fluorescence, and other optical techniques, ultrahigh-resolution OCT (µOCT) where the resolution is sufficiently detailed to visualize individual cells, and functional OCT that measures the function and metabolism of cells in living systems. These technologies are implemented in a variety of devices (endoscopes, catheters, capsules, ...

Postdoctoral Fellows/Research Scientists at University of Washington, Seattle

The Biophotonics and Imaging Lab at the University of Washington is inviting applications for 4 research associates and research scientists to advance optical imaging developments, especially optical coherence tomography (OCT), including clinical translational developments. We expect the candidates to be highly motivated, technically skilled, and forward-thinking. We offer a competitive salary with a minimum level of $60k, up to $75k commensurate with experience. The positions are full-time employments, and the contract will be renewed on a yearly basis with a maximum period of 5 years on the position depending on the candidate’s performance.   Biophotonics and Imaging Lab is a state-of-the-art research and clinical translational facility occupying 3,000 sqft research space at the beautiful and vibrant main campus, with additional two satellite clinical labs located within the Department of Ophthalmology (at the downtown Seattle). The lab develops imaging technologies sta...

Perimeter Medical Imaging AI Announces Publication of Peer-Reviewed Journal Article Validating Potential Use of Wide-Field Optical Coherence Tomography (WF-OCT) in Head and Neck Surgeries

Perimeter Medical Imaging AI, Inc. (TSX-V: PINK)(OTC: PYNKF) (FSE: 4PC) (“Perimeter” or the “Company”) announced the publication of a peer-reviewed research article in JAMA Otolaryngology—Head and Neck Surgery . The study’s findings validate the further exploration of the use of Perimeter’s wide-field Optical Coherence Tomography (WF-OCT) technology to visualize margins during head and neck surgeries. The research study, conducted at Mount Sinai Icahn School of Medicine, included 53 adult patients undergoing primary ablative surgery of the oral cavity or oropharynx for squamous cell carcinoma (SCC). Resected specimens were imaged with Perimeter S-Series OCT in the operating room prior to routine pathology to allow for post-operative comparisons. Arvind K. Badhey, MD, Department of Otolaryngology, University of Massachusetts Chan Medical School, and lead author, stated, “We understand that SCC patients with positive margins after initia...

Pre- and Post-doctoral Positions in Biomedical Optics and Biomechanics Opening at University of Houston

The Biomedical Optics Laboratory (http://bol.egr.uh.edu) in the Department of Biomedical Engineering at the University of Houston, TX invites applications for pre- and post-doctoral positions in the area of biomedical optical imaging, photoacoustics, and biomechanics. Documented experience in one of the following areas is required: optical coherence tomography (OCT), opto(photo)acoustics, light-sheet microscopy (instrumentation and software development), optical elastography/biomechanics, and Brillouin Spectroscopy. The successful applicants will join a dynamic team to work on projects such as optical methods to study tissue (ocular, skin, heart) biomechanics and develop advanced optical methods for developmental biology. Excellent opportunities exist for collaboration with clinicians from Texas Medical Center.  Responsibilities include: Development and maintenance of advanced optical imaging systems (such as OCT, optical projection tomography, photoacoustics, Brillouin m...

Lymphography method based on time-autocorrelated optical coherence tomography

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Lymphatic vessels are structurally similar to blood vessels, and the lymphatic fluid flowing within the lymphatic vessels is distributed throughout the body and plays a vital role in the human immune system. Visualization of the lymphatic vessels is clinically important in the diagnosis of tumor cell metastasis and related immune system diseases, but lymph is difficult to image due to its near-transparent nature and low flow rate. In this paper, we present a lymphography method based on time-autocorrelated optical coherence tomography. By using the minimum value difference of the autocorrelation function of the time-varying interference intensity between the lymph and the surrounding tissues, the non-invasive and high-sensitivity imaging of lymph vessels can be achieved. The method proposed in this paper has potential significance for the research and treatment of immune system diseases. ( Read Full Article )

Research Assistant / Research Associate Opening at University of Kent

Physics and Astronomy Location:  Canterbury Salary:  £28,762 to £40,931 per annum   Research Assistant (Grade 6): £28,762 - £32,348 per annum / Research Associate (Grade 7): £36,386 – 40,931 per annum Grade:  Grade 6 Research Assistant to Grade 7 Post Type:  Full Time Contract Type: Fixed Term - 36 Months Release Date:  Friday 11 November 2022 Closing Date:  23.59 hours BST on Friday 02 December 2022  (unless otherwise stated) Interview Date:  To be confirmed Reference:  NATS-159-22-R We are looking for an enthusiastic and ambitious researcher to join the Applied Optics Group (AOG) in the School of Physics and Astronomy at the University of Kent.  You will work in the field of miniaturised endoscopic optical coherence tomography (OCT) on a project supported by the EPSRC grant, “FoVEnOCT: Compact Forward-Viewing Endoscopic Optical Coherence...

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