Yavuz Çakır

Machine Learning-Based Automated Detection and Quantification of Geographic Atrophy and Hypertransmission Defects Using Spectral Domain Optical Coherence Tomography

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The current study describes the development and assessment of innovative, machine learning (ML)-based approaches for automated detection and pixel-accurate measurements of regions with geographic atrophy (GA) in late-stage age-related macular degeneration (AMD) using optical coherence tomography systems. 900 OCT volumes, 100266 B-scans, and en face OCT images from 341 non-exudative AMD patients with or without GA were included in this study from both Cirrus (Zeiss) and Spectralis (Heidelberg) OCT systems. B-scan and en face level ground truth GA masks were created on OCT B-scan where the segmented ellipsoid zone (EZ) line, retinal pigment epithelium (RPE) line, and bruchs membrane (BM) line overlapped. Two deep learning-based approaches, B-scan level and en face level, were trained. The OCT B-scan model had detection accuracy of 91% and GA area measurement accuracy of 94%. The en face OCT model had detection accuracy of 82% and GA area measurement accuracy of 96% with primary target...

Spectral Domain Optical Coherence Tomography Findings in Carotid Artery Disease

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Carotid artery disease (CAD) is characterized by stenosis or occlusion in the carotid arterial system. The most common cause of obstruction is atherosclerosis of the carotid artery, although inflammatory conditions such as giant cell arteritis, fibromuscular dysplasia, and Behçet’s disease can occasionally be responsible.1 According to the degree of involvement, especially when the internal carotid artery (ICA) is affected, this may lead to ipsilateral reduced retinal blood flow and eventually progress to ocular ischemic syndrome (OIS). OIS is a rare condition, but its complications may cause severe visual impairment. Most CAD patients have no ocular symptoms when OIS occurs except transient visual loss (amaurosis fugax). Retinal examination may not reveal additional findings at first. As the retinal ischemia becomes chronic, signs and symptoms (mild to severe vision loss, ocular pain, narrowed retinal arteries, dilated but nontortuous retinal veins, and midperipheral d...

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