Foveal avascular zone in normal human eyes by optical coherence tomography angiography

January 24, 2023 | Ophthalmology

Guisen Zhang, Guoqiang Zhang, Han Zhang, Huixia Li, Jie She, Xiaoguang Zhang, Yunlei Pan

Objective To analyze the influence factors of the area of superficial plexus foveal avascular zone (FAZ) and related indexes of fovea measured with optical coherence tomography angiography (OCT-A) in normal subjects. Methods This was a cross-sectional study from November 2020 to May 2021 in the Inner Mongolia Autonomous Region, China. Each subject received related eye examination. The correlation between all the factors and superficial plexus FAZ were analyzed under univariable and multivariable linear regression analysis. Results Finally, 239 subjects with sufficient data were recruited in the study, including 108 males and 131 females, aged 27.41±4.63 years. The area of superficial plexus FAZ was 0.33±0.16 mm2. In the univariate regression, gender (β = 41.702, 95%CI: 9.152 to 74.253, P = 0.012), drinking (β = -66.074, 95%CI: -99.197 to -32.951, P = 0.001) and axial length (β = -15.874, 95%CI: -29.562 to -2.185, P = 0.023) were associated with superficial plexus FAZ area. In m...

A prototype hybrid intraoperative probe for ovarian cancer detection

April 19, 2009 | Gynecology, Oncology, Probes | Organization, University of Connecticut

John Gamelin, Molly Brewer, Mozafareddin Karemeddini, Nrushingh Biswal, quing zhu, Shikui Yan, Xiaoguang Zhang, Yi Yang, yueli chen

A novel prototype intraoperative system combining positron detection and optical coherence tomography (OCT) imaging has been developed for early ovarian cancer detection. The probe employs eight plastic scintillating fiber tips for preferential detection of local positron activity surrounding a central scanning OCT fiber providing volumetric imaging of tissue structure in regions of high radiotracer uptake. Characterization measurements of positron sensitivity, spatial response, and position mapping are presented for Tl204/Cs137 sources as well as 18F-FDG. In conjunction with co-registered frequency domain OCT measurements the results demonstrate the potential for a miniaturized laparoscopic probe offering simultaneous functional localization and structural imaging for improved early cancer detection. ( Read Full Article )